| 小鼠慢性皮炎-湿疹模型的建立 |
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| 引用本文： | 金慧玲,张汝芝,余其斌.小鼠慢性皮炎-湿疹模型的建立[J].蚌埠医学院学报,2002,27(3):193-194. |
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| 作者姓名： | 金慧玲 张汝芝 余其斌 |
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| 作者单位： | 蚌埠医学院附属医院,皮肤科,安徽,蚌埠,233004 |
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| 摘 要： | 目的:用小鼠建立慢性皮炎-湿疹模型.方法:用7%二硝基氯苯(DNCB)外涂小鼠背部致敏,5天后用0.1% DNCB于小鼠右耳内侧反复激发引起慢性皮炎的模型,每隔3天激发1次,对照组于激发后外用氢化可的松,两组进行对比观察.结果:实验组小鼠耳部出现肿胀增厚、表面结痂、炎性细胞浸润增多,对照组的变化则不明显.结论:小量DNCB反复刺激小鼠耳部可建立慢性皮炎-湿疹模型,而外用氢化可的松后可抑制该模型成立.
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| 关 键 词： | 皮炎 湿疹 动物 实验 |
| 文章编号： | 1000-2200(2002)03-0193-02 |
| 修稿时间： | 2001年6月10日 |
Model of chronic dermatitis-eczema in mice |
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| JIN Hui ling,ZHANG Ru zhi,YU Qi bin.Model of chronic dermatitis-eczema in mice[J].Journal of Bengbu Medical College,2002,27(3):193-194. |
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| Authors: | JIN Hui ling ZHANG Ru zhi YU Qi bin |
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| Abstract: | Objective:To establish the model of chronic dermatitis eczema in mice.Methods:Right ears of CXA 1 mice which were previously sensitized with 7% dinitrochlorobenzen(DNCB) were repeatedly challenged with 0.1% DNCB for five time.The controls were applied hydrocortisone after each challenge.Results:After 4th and 5th challenges,changes such as ear swelling thickening,crusts and cellular infiltrates in dermis were observed,and these features seemed to be more significant in vehicle treated mice compared to hydrocortisone controls.Conclusions:Repeated challenges with a small dose of DNCB may induce chronic dermatitis eczema in mice,while application of hydrocortisone can inhibit these responses. |
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| Keywords: | dermatitis eczema animal experiment |
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