The recycling endosome and its role in neurological disorders |
| |
Authors: | Li Xueyi DiFiglia Marian |
| |
Affiliation: | Laboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA. |
| |
Abstract: | The recycling endosome (RE) is an organelle in the endocytic pathway where plasma membranes (proteins and lipids) internalized by endocytosis are processed back to the cell surface for reuse. Endocytic recycling is the primary way for the cell to maintain constituents of the plasma membrane (Griffiths et al., 1989), i.e., to maintain the abundance of receptors and transporters on cell surfaces. Membrane traffic through the RE is crucial for several key cellular processes including cytokinesis and cell migration. In polarized cells, including neurons, the RE is vital for the generation and maintenance of the polarity of the plasma membrane. Many RE dependent cargo molecules are known to be important for neuronal function and there is evidence that improper function of key proteins in RE-associated pathways may contribute to the pathogenesis of neurological disorders, including Huntington's disease. The function of the RE in neurons is poorly understood. Therefore, there is need to understand how membrane dynamics in RE-associated pathways are affected or participate in the development or progression of neurological diseases. This review summarizes advances in understanding endocytic recycling associated with the RE, challenges in elucidating molecular mechanisms underlying RE function, and evidence for RE dysfunction in neurological disorders. |
| |
Keywords: | AD, Alzheimer's disease AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid APP, amyloid precursor protein CHO, Chinese hamster ovary EAAC1, excitatory amino acid carrier 1 EAAT3, excitatory amino acid transporter 3 EE, early endosome EHD, Eps15 homology (EH) domain containing protein (EHD) ER, endoplasmic reticulum ES, embryonic stem GAP, GTPase-activating protein GDF, GDI-displacement factor GEF, guanine nucleotide exchange factor HD, Huntington's disease HRP, horseradish peroxidase Htt, huntingtin LE, late endosome α2-M, α2-microglobulin MDCK, Madin–Darby canine kidney PrP, prion protein Rab11FIP, Rab11 family interacting protein rabGDI, rabGDP dissociation inhibitor RE, recycling endosome SE, sorting endosome SH3TC2, Src homology 3 domain and tetratricopeptide repeat 2 SNARE, soluble N-ethylmaleimide-sensitive factor attachment protein receptor Tfn, transferrin TfnR, transferrin receptor TNFα, tumor necrosis factor α tTGase, tissue transglutaminase VAMP, vesicle-associated membrane protein |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|