Population-based study of DNA image cytometry as screening method for esophageal cancer |
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Authors: | Zhao Lin Wei Wen-Qiang Zhao De-Li Hao Chang-Qing Lin Dong-Mei Pan Qin-Jing Li Xin-Qing Lei Fu-Hua Wang Jin-Wu Wang Guo-Qing Shang Qi Qiao You-Lin |
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Affiliation: | Department of Cancer Epidemiology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. |
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Abstract: | AIM: To explore the DNA image cytometry (DNA-ICM) technique as a primary screening method for esophageal squamous precancerous lesions.METHODS: This study was designed as a population-based screening study. A total of 582 local residents aged 40 years-69 years were recruited from Linzhou in Henan and Feicheng in Shandong. However, only 452 subjects had results of liquid-based cytology, DNA-ICM and pathology. The sensitivity and specificity of DNA-ICM were calculated and compared with liquid-based cytology in moderate dysplasia or worse.RESULTS: Sensitivities of DNA-ICM ranging from at least 1 to 4 aneuploid cells were 90.91%, 86.36%, 79.55% and 77.27%, respectively, which were better than that of liquid-based cytology (75%). Specificities of DNA-ICM were 70.83%, 84.07%, 92.65% and 96.81%, but the specificity of liquid-based cytology was 91.91%. The sensitivity and specificity of a combination of liquid-based cytology and DNA-ICM were 84.09% and 85.78%, respectively.CONCLUSION: It is possible to use DNA-ICM technique as a primary screening method for esophageal squamous precancerous lesions. |
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Keywords: | DNA image cytometry Aneuploidy Screening Esophageal cancer Precancerous lesions |
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