Anti-inflammatory and analgesic effects of Yaotuitong Capsules in experimental rats with chemically induced radicular neuritis

Objective

The aims of this study were to determine the anti-inflammatory and analgesic effects of Yaotuitong (translation: low back and leg pain) capsules, a Chinese herbal preparation, and the histological changes it induces in experimental rats with chemically induced radicular neuritis.

Methods

Wistar rats were randomly divided into normal, model, Western medicine, and traditional Chinese medicine groups (n=24 per group). We surgically duplicated a chemical radicular neuritis model to simulate lumbar intervertebral disc protrusion. Granuloma formation was measured on postoperative days (PODs) 3, 7, 14, and 21. Prostaglandin E₂ and 5-hydroxytryptamine (inflammation mediators) levels in the surrounding tissue and the histology of the nerve root were determined on PODs 7 and 14.

Results

Yaotuitong capsules significantly reduced prostaglandin E₂ (P<0.01) and 5-hydroxytryptamine (P<0.01) levels in tissue surrounding the nerve root. It also inhibited granuloma formation (P<0.05).

Conclusion

Yaotuitong capsules have anti-inflammatory and analgesic effects that can alleviate the discomfort of lumbar intervertebral disc protrusion.