Energy metabolism in kaolin-induced hydrocephalic rat brain |
| |
| Authors: | M. Matsumae T. Sogabe I. Miura O. Sato |
| |
| Affiliation: | (1) Department of Neurosurgery, Tokai University School of Medicine, Bohseidai, Isehara, 259-11 Kanagawa, Japan;(2) Bioenergy Research Center, Tokushima Institute, Otsuka Pharmaceutical Co., Kawauchi-cho, 771-01 Tokushima, Japan;(3) Present address: Department of Neurosurgery, The Children's Hospital, Harvard Medical School, 300 Longwood Avenue, 02115 Boston, MA, USA |
| |
| Abstract: | Energy metabolism in kaolin-induced hydrocephalic rat brain was assessed by means of 31-phosphorus magnetic resonance spectroscopy and measurement of the activity of lactate dehydrogenase (LDH) as well as its isoenzyme patterns. Decreases in beta-adenosine triphosphate and phosphocreatine were observed in hydrocephalic rat brains. While the intracellular pH was decreased at 2 to 4 weeks, it showed some recovery 6 weeks after injection of kaolin. The activity of LDH increased in the hydrocephalic state, and its isoenzyme-pattern changes were as follows: the LDH5 fraction was predominant in 1-week to 4-week rats while the LDH4 fraction was predominant in 4-week rat brains, and at 6-weeks, the LDH4 and LDH5 fractions were decreased. These data from rat brains with kaolin-induced hydrocephalus indicate that anaerobic glycolysis is the primary pathway of energy metabolism in the acute hydrocephalic state, while in the chronic state the emphasis shifts to aerobic glycolysis.Presented at the 17th Annual Meeting of Pediatric Section of the American Association of Neurological Surgeons, Arizona 1988 |
| |
| Keywords: | Hydrocephalus Cerebral energy metabolism 31P-MRS High-energy phosphorus compound Lactate dehydrogenase Isoenzyme |
| 本文献已被 SpringerLink 等数据库收录！ |
|
