Comparing cystatin C and creatinine in the diagnosis of pediatric acute renal allograft dysfunction |
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| Authors: | Slort Pauline R Ozden Nergiz Pape Lars Offner Gisela Tromp Wilma F Wilhelm Abraham J Bokenkamp Arend |
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| Affiliation: | (1) Department of Pediatric Nephrology, VU University Medical Center, Postbox 7057, 1007 MB Amsterdam, The Netherlands;(2) Pediatric Nephrology, Hannover Medical School, Hannover, Germany;(3) Pediatric Nephrology, Academic Medical Center, Amsterdam, The Netherlands;(4) Clinical Pharmacology and Pharmacy, VU University Medical Center, Amsterdam, The Netherlands; |
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| Abstract: | Background Allograft function following renal transplantation is commonly monitored using serum creatinine. Multiple cross-sectional studies have shown that serum cystatin C is superior to creatinine for detection of mild to moderate chronic kidney dysfunction. Recent data in adults indicate that cystatin C might also be a more sensitive marker of acute renal dysfunction. This study aims to compare cystatin C and creatinine for detection of acute allograft dysfunction in children using pediatric RIFLE (risk of renal dysfunction, injury to the kidney, failure or loss of kidney function, end stage renal disease) criteria for acute kidney injury. |
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