部分脱抗原同种异体牙本质盖髓剂的临床应用研究

目的 :评价部分脱抗原同种异体牙本质 (HPDD)盖髓剂的疗效 ,为临床盖髓剂的选择提供依据。方法 :以HPDD、氢氧化钙 (CH)两种材料盖髓剂 ,进行临床远期疗效观察。结果 :HPDD间接盖髓成功率 10 0 % ,直接盖髓成功率 87 88% ;CH组间接盖髓成功率 94 87% ,直接盖髓成功率 80 6 5 % ,两组盖髓剂临床成功率统计学分析无显著差异性 ,P >0 0 5。结论 :两组盖髓剂临床效果良好 ,HPDD抗原性弱 ,不产生免疫反应 ,对牙本质修复有促进作用 ,是可选择的盖髓剂。

Effect of homologue partly deantigen dentinum (HPDD) as pulp capping agent on deep caries and pulpitis

Objective:To evaluate the effect of HPDD as pulp capping agents on deep caries and pulpitis. Methods:HPDD and calcium hydroxide (CH) were chosen as pulp capping agents and 2-year-follow-up observation was performed. A total of 150 teeth (80 deep caries and 70 reducible pulpitis) was randomly divided into four groups: HPDD indirect pulp capping group (n=40), HPDD direct pulp capping group (n=35), CH indirect pulp capping group (n=40), and CH direct pulp capping group (n=35). Bite-wing radiograph and pulp vitality test were employed to assess the therapeutic effect.Results:The success rates in HPDD indirect pulp capping group, HPDD direct pulp capping group, CH indirect pulp capping group and CH direct pulp capping were 100%, 87.88%, 94.87%, and 80.65%, respectively. Statistical analysis showed no significant difference of success rate in clinic between the two pulp capping agents. Conclusion:Both HPDD and CH are effective on deep caries and reducible pulpitis, but HPDD is of weak antigenicity and no immunoreactions. Therefore, HPDD may be considered as an ideal pulp-capping agent.