不同药物膀胱灌注化疗对膀胱癌术后复发的影响

目的探讨不同药物膀胱灌注化疗对膀胱癌术后复发的疗效差异。方法 95例符合入选标准的非肌层浸润性膀胱尿路上皮癌患者,经尿道膀胱肿瘤电切术后被随机分为3组行早期加维持性膀胱内灌注：羟基喜树碱（HCPT）组31例;丝裂霉素（MMC）组32例;顺铂（DDP）组32例。随访2年,观察有无复发。结果 95例术后随访2年。HCPT组31例中9例复发,复发率29.0%;MMC组32例中10例复发,复发率31.3%;DDP组32例中10例复发,复发率31.3%,各组间复发率差异无统计学意义（P〉0.05）。结论 HCPT、MMC、DDP膀胱灌注化疗均能达到降低肿瘤复发的疗效。

The effect of intravesical instillation with different drugs on postoperative recurrence of bladder cancer

Objective To evaluate the effect of intravesial instillation with different drugs on postoperative recurrence of bladder cancer.Methods A total of 95 non muscle-invasive bladder transitional cell cancers who underwent transurethral resection of bladder tumor （TURBT） were divided into 3 groups randomly：31 patients received intravesial instillation of hydroxycamptothecin （HCPT）;32 patients in mitomycin C （MMC）,and 32 patients in diamminedichloroplatinum （DDP）.All the patients were followed up to study the recurrence for 2 years.Results 9 patients had recured in HCPT group,10 patients in MMC group,and 10 patients in DDP group.The tumor recurrence rate in HCPT group was 29.0% （9/31）,MMC group was 31.3% （10/32）,and DDP group was 31.3% （10/32）.There was no significant difference between HCPT group,MMC group and DDP group（P0.05）.Conclusions HCPT,MMC and DDP have the similar efficacy for preventing postoperative recurrence of bladder cancer.