| P504S、EZH2和pim-1在前列腺癌组织中的表达和意义 |
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| 引用本文： | 张世革,邱雁,邱梁,吴烨,丁毅.P504S、EZH2和pim-1在前列腺癌组织中的表达和意义[J].中国医学文摘(检验与临床),2010(6):354-356. |
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| 作者姓名： | 张世革 邱雁 邱梁 吴烨 丁毅 |
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| 作者单位： | [1]江苏省老年医院泌尿外科,南京210024 [2]江苏省老年医院病理科,南京210024 |
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| 摘 要： | 目的探讨P504S、EZH2和pim-1在前列腺癌组织中的表达和意义。方法采用免疫组织化学技术检测P504S、EZH2和pim-1在前列腺癌和前列腺增生中的表达，分析其表达水平与Gleason评分的关系。结果P504S、EZH2和pim-1在前列腺癌中均为明显高表达，其与Gleason评分的相关性分别为0．418（P〈0．05）、0．268（P〉0．05）和0．567（P〈0．01）。结论P504S、EZH2和pim-1对前列腺癌均具有高度敏感性和特异性，其表达强度与Gleason评分存在一定的相关性，对前列腺癌的预后判断有参考价值。
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| 关 键 词： | 前列腺肿瘤 P504S EZH2 pim- 1 |
Expressions and significance of P504S, EZH2 and pim-1 in prostate cancer |
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| Authors: | ZHANG Shi-ge QIU Yah QIU Liang WU Ye DING Yi |
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| Institution: | . Department of Urology, J iangsu Geriatric Hospital, Nan- jing 210024, China |
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| Abstract: | Objective To determine the expression of P504S, EZH2 and pim-1 in prostate cancer and its correlation with Gleason score. Methods Immunohistoehemical stain was used to study the expression of P504S,EZH2 and pim-1 in prostate cancer and benign prostate hyperplasia. Its expression level was analysed with respect to Gleason score. Results P504S, EZH2 and pim-1 was overexpressed in prostate cancer. And Gleason score was positively correlated with P504S （0.418 ,P〈0.05）, EZH2（0.268,P〈0.05） and pim- 1（0.567, P〈0.01）. Conclusions P504S, EZH2 and pim-1 are sensitive and specific marker for prostate cancer. The expression level of P5048, EZH2 and pim-1 was related to Gleason score. |
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| Keywords: | Prostate neoplasms P504S EZH2 pim-1 |
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