Cardiopulmonary morbidity and quality of life in non-small cell lung cancer patients treated with or without postoperative radiotherapy |
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Authors: | Lucyna Kepka Krzysztof Bujko Tadeusz M OrlowskiRobert Jagiello Andrzej SalataMiroslawa Matecka-Nowak Henryk JanowskiDanuta Rogowska |
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Institution: | a Department of Radiotherapy, The Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw, Poland b Department of Surgery, The Institute of Tuberculosis and Lung Diseases, Warsaw, Poland c Department of Radiotherapy, Holycross Cancer Center, Kielce, Poland d Department of Radiotherapy, The Greater Poland Cancer Centre, Poznan, Poland e Thoracic Surgery Department of the Regional Hospital for Lung Diseases, Szczecin, Poland f Department of Radiotherapy, Pomeranian Medical University, Szczecin, Poland |
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Abstract: | AimTo prospectively assess the cardiopulmonary morbidity and quality of life in patients with non-small cell lung cancer (NSCLC) treated with postoperative radiotherapy (PORT) in comparison to those not receiving PORT.Materials and methodsFrom 2003 to 2007, 291 patients entered the study; 171 pN2 patients received 3D-planned PORT (PORT group), 120 pN1 patients (non-PORT group) did not. One month after surgery, all patients completed EORTC QLQ C-30 questionnaire and had pulmonary function tests (PFT); cardiopulmonary symptoms were assessed by modified LENT-SOM scale. Two years later, disease-free patients repeated the same examinations. The differences between baseline values and values recorded at two years in QLQ, LENT-SOM and the PFT of the two groups were compared.ResultsIn the whole cohort, the rate of non-cancer related deaths was 5.3% and 5.0% in PORT and non-PORT group, respectively. Ninety-five patients (47 - PORT group, 48 - non-PORT group) were included into the final analysis. The differences in the QLQ and cardiopulmonary function (LENT/SOM, PFT) between both groups were insignificant. The forced expiratory volume in one second was on average 12.2% and 1.3% better in the PORT and the non-PORT group, respectively, p = 0.2.ConclusionsOur findings support the hypothesis about insignificant morbidity of 3D-planned PORT. |
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Keywords: | Non-small cell lung cancer Postoperative radiotherapy Cardiopulmonary morbidity Quality of life Pulmonary function tests |
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