| 青蒿素抗肿瘤作用的初步研究 |
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| 引用本文： | 路景涛,魏伟,陈敏珠.青蒿素抗肿瘤作用的初步研究[J].安徽医药,2007,11(1):14-15. |
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| 作者姓名： | 路景涛 魏伟 陈敏珠 |
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| 作者单位： | 安徽医科大学临床药理研究所,安徽,合肥,230032;安徽医科大学临床药理研究所,安徽,合肥,230032;安徽医科大学临床药理研究所,安徽,合肥,230032 |
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| 基金项目： | 安徽医科大学校科研和教改项目 |
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| 摘 要： | 目的 研究菊科植物黄花蒿的单体青蒿素(Artimisinine, ART)的抗肿瘤作用.方法 采用动物移植性肿瘤实验方法.结果 50 mg·kg-1 ART对小鼠移植性肉瘤S180的抑瘤率为37.88%;100 mg·kg-1 ART对小鼠移植性肝癌Heps实体瘤的抑瘤率为35.23%;ART对艾氏腹水癌EAC小鼠生命延长率无统计学意义.结论 ART具有良好的抗肿瘤作用.
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| 关 键 词： | 青蒿素 抗肿瘤 S180 Heps EAC |
| 文章编号： | 23672178 |
| 修稿时间： | 08 3 2006 12:00AM |
A preliminary tudy on antitumor activity of artimisinine |
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| LU Jing-tao,WEI Wei,CHEN Min-zhu.A preliminary tudy on antitumor activity of artimisinine[J].Anhui Medical and Pharmaceutical Journal,2007,11(1):14-15. |
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| Authors: | LU Jing-tao WEI Wei CHEN Min-zhu |
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| Institution: | Institute of Clinical Phurrnacology,Anhui Medical University,Hefei 230032 |
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| Abstract: | Aim To study the antitumor activity of artimisinine(ART).Methods By using experimental models of sarcoma 180,hepatoma (Heps) and Ehrlich ascilic carcinoma (EAC) in mice,the inhibitory rates of tumor weight of S180 and Heps mice were tested, and prolonging lifespan of EAC mice was detected.Results ART could inhibit the growth of tumor cells of S180 and Heps in mice,and increase lifespan of EAC mice.Conclusion ART possessed significant antitumor activity. |
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| Keywords: | artimisinine antitumor S180 Heps EAC |
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