冠心病患者外周血血脂与载脂蛋白A1和载脂蛋白B100水平关系的研究

目的探讨冠心病（CHD）患者外周血脂和载脂蛋白的表达水平及其临床意义。方法选择120例冠心病患者（CHD组），检测其总胆固醇（TC）、三酰甘油（TC）、低密度脂蛋白胆回醇（LDL—C）、高密度脂蛋白胆固醇（HDL—C）和载脂蛋白A1（APOA1）、载脂蛋白B100（APOB100）的水平，并选择同期健康体检者60名作为健康对照组。结果与对照组相比，冠心病患者外周血TG、TC、LDL—C、APOB100升高，而HDL—C、ApoA1水平下降，差异均有统计学意义（P〈0．05）。CHD组患者HDL—C水平与APOA1水平呈正相关（P〈0．05），LDL—C水平与APOB100水平亦呈正相关（P〉0．05）。结论冠心病患者外周血脂和载脂蛋白异常，血脂及脂蛋白可作为冠心病患者危险因素的重要指标．联合检测有助于冠心病的早期诊断．

Coronary Disease Patient Circumference Blood Blood Fats with Carry the Lipoprotein A1(APOA1),Carry Lipoprotein B100 Horizontal Relationship Research

Objective The goal discussion coronary disease （CHD） patient circumference blood fats and carry the lipoprotein the expression horizontal and the clinical significance. Methods The method chooses 120 example coronary disease patient （the CHD group）, examines its total cholesterol （TC）, glycerin （TG）, low density lipoprotein cholesterol （LDL- C）, high density lipoprotein cholesterol （ HDL - C ） and carries the lipoprotein A1 （ APOA1 ）, carries the lipoprotein B100 （APOB100） level, and chooses the same time healthy physical examination 60 celebrated works is the healthy control group. Results The result and the control group compare, coronary disease patient circumference blood TG, TC, LDL - C, APOB100 ascension, but HDL - C, the APOA1 level drops, the difference has statistics significance （ P 〈 0. 05）. CHD the group patient HDL - C level and the APOA1 level present is connected the （ P 〈 0. 05）, LDL - C level and the APOB100 level also presents is connected （ r = 0. 486, P 〉 0. 05）. Conclusion The conclusion coronary disease patient circumference blood fats and carry the lipoprotein to be unusual, the blood fats and the lipoprotein may take the coronary disease patient dangerous factor the important target, the union examination is helpful to coronary disease early diagnosis.