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450例住院儿童药物不良反应报告分析
引用本文:郭向阳,王侠,严晓华,焦富勇,王杰民. 450例住院儿童药物不良反应报告分析[J]. 儿科药学, 2014, 0(5): 48-50
作者姓名:郭向阳  王侠  严晓华  焦富勇  王杰民
作者单位:陕西省人民医院,陕西西安710068
摘    要:目的:探讨住院儿童药物不良反应的临床特点,指导临床合理用药。方法:收集我院2009-2012年临床报告的住院儿童药物不良反应(ADR)450例,统计分析患儿性别、年龄、相关药物、给药途径、ADR主要的临床表现等情况。结果:450例ADR患儿中,男235例(52.2%),女215例(47.8%),≤3岁318例(70.7%);以抗微生物药(289/450,64.2%)、中药制剂(58/450,12.9%)所致ADR居多;静脉滴注给药(349/450,77.6%)最易引起ADR;多发生在给药后1 h内(281/450,62.4%);ADR临床表现以皮肤及其附件损害为主(356/450,79.1%)。结论:临床应重视儿童ADR发生的相关因素,合理用药,尽量避免多重用药,以防止ADR发生。

关 键 词:儿童  药物不良反应  合理用药

Analysis of 450 Cases with Adverse Drug Reactions in Hospitalized Children
Guo Xiangyang,Wang Xia,Yah Xiaohua,Jiao Fuyong,Wang Jiemin. Analysis of 450 Cases with Adverse Drug Reactions in Hospitalized Children[J]. Journal of Pediatric Pharmacy, 2014, 0(5): 48-50
Authors:Guo Xiangyang  Wang Xia  Yah Xiaohua  Jiao Fuyong  Wang Jiemin
Affiliation:(Shanxi Provincial People' s Hospital, Shanxi Xi' an 710068, China)
Abstract:Objective: To study the clinical characteristics of adverse drug reactions in children, and to guide the clinical rational use of drug. Methods: Four hundreds and fifty cases of adverse drug reactions in hospitalized children were collected, and clinical data were analyzed. Results: There were more adverse drug reactions in the children under 3 years old (318/450, 70.7% ); adverse drug reactions were mostly caused by anti-microbial agents (289/450, 64.2% ) and traditional Chinese medicines (58/450, 12.9% ) ; vein administration (349/450, 77.6% ) caused more drug adverse reactions; there were more adverse drug reactions occurred within 1 hour after administration (281/450, 62.4% ) ; the most common clinical manifestation of adverse drug reactions was the damage of skin and its appendages (356/450, 79.1% ). Conclusions: It should be paid more attention to the related factors of children' s adverse drug reactions. The rational use of drugs and avoiding multiple drugs using as far as possible would prevent the occurrence of adverse drug reactions.
Keywords:Children  Adverse drug reactions  Rational use of drug
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