槐杞黄颗粒联合孟鲁司特钠治疗儿童咳嗽变异性哮喘临床观察

目的：探讨槐杞黄颗粒联合孟鲁司特钠治疗儿童咳嗽变异性哮喘的疗效及其对肺功能、免疫功能的影响。方法：选取我院2012年1月至2013年1月收治的咳嗽变异性哮喘患儿48例，随机分为观察组和对照组各24例，均给予止咳、支气管扩张剂、抗过敏等常规治疗。观察组加用孟鲁司特钠（2～6岁每次4mg，〉6岁～12岁每次5mg，每晚1次口服）和槐杞黄颗粒（2～3岁每次5g，〉3岁～12岁每次10g，早晚各1次口服）治疗，对照组仅加用孟鲁司特钠治疗，用法用量同观察组，均连续治疗3个月。治疗3个月后比较两组临床疗效、咳嗽缓解及消退时间、肺功能和免疫功能指标变化。随访6个月，观察复发情况。结果：观察组和对照组总有效率（91．7％vs79．2％）比较差异无统计学意义（P〉0．05），但观察组咳嗽症状缓解和消失时间均短于对照组（P〈0．05）。两组FEV1％、PEF％、IgE、CD4＋T细胞、CD8＋T细胞水平及CD4＋／CD8＋均较治疗前改善，且观察组改善程度更大（P〈0．01）。两纽随访6个月复发率比较差异无统计学意义（P〉0．05）。结论：在常规治疗基础上加用槐杞黄颗粒联合盂鲁司特钠治疗儿童咳嗽变异性哮喘，不仅具有良好的临床疗效，还能缩短咳嗽缓解及消失时间，能更好地改善患儿肺功能及免疫功能，体现了中西医结合治疗“多途径、多靶点”的整体优势。

Clinical Effects of Huaiqihuang Particle Combined with Montelukast Sodiumin Treated Children with Cough Variant Asthma

Objective： To investigate the clinical effects of Huaiqihuang particle combined with montelukast sodium on lung and immune function of children with cough variant asthma. Methods： Forty-eight children of our hospital with cough variant asthma were chosen for the research objects. They were randomly divided into an observation group and a control group （ n = 24 cases each）. Both groups were given conventional treatment such as suppressing cough, bronchodilator and anti-allergics. On the basis of conventional treatment, the observation group was given Huaiqihuang particle （ children of 2 - 3 years old 5 mg per time, 3 - 12 years old 10 mg per time, twice a day each morning and evening, orally） combined with montelukast sodium （ children of 2 - 6 years old 4 mg per time, 6 - 12 years old 5 mg per time, once a day each evening, orally） ; the control group was only given montelukast sodium. After three months＇ treatment, the clinical efficacy, cough relieving, and relevant indicators＇ changes of lung and immune function were comparatively analyzed. The recurrence was observed during six months＇ follow-up. Results： After three months＇ treatment, the total effective rate of the observation group （91.7%） were higher than that of the control group （79.2%）, but the difference had no statistical significance （ P〉0. 05 ）. The length of cough relief in the observation group were significantly shorter than that in the control group ; the difference had statistical significance （P〈0.05）. The FEV1% , PEF, IgE, CD4＋T cell, CD8＋T levels and CD4＋/CD8＋ ratio of the two groups were significantly improved after treatment （P〈0.01）. After six months＇ treatment, the recurrence rate of the observation group was lower than that of the control group, but the difference had no statistical significance （P〉0.05）. Conclusions： Children with cough variant asthma treating with Huaiqihuang particle combined with montelukast sodium on the basis of conventional treatment, has good clinical curative effect, it can shorten the length of cough re fief, improve the children＇s lung and immune function and reduce the recurrence rate. It embodies advantages of combining Traditional Chinese and Western Medicine therapy.