甲氨蝶呤治疗类风湿关节炎的不良反应分析

目的以类风湿性关节炎为基础疾病,研究甲氨蝶呤在治疗过程中的不良反应以及预防措施。方法选取2002年1月—2012年1月于我院治疗类风湿性关节炎患者102例,随机分为TG组以及OG组,每组各51例。OG组服用甲氨蝶呤,TG组在此基础上加用叶酸,疗程为24周,观察患者治疗前后红细胞沉降率(ESR)、C反应蛋白(CRP)以及类风湿因子(RF)等指标,比较两组不良反应发生率。结果两组患者疗效差异无统计学意义(P>0.01),TG组的不良反应发生率明显小于OG组,差异有统计学意义(P<0.01)。结论叶酸可以减少甲氨蝶呤不良反应的发生,同时对治疗效果没有明显影响,两者可以联合使用。

The Analysis of Adverse Effect of Methotrexate to Treat Rheumatoid Arthritis

Objective To discuss the adverse effect and prevetion of methotrexate to treat rheumatoid arthritis. Meth- ods Choosed 102 cases of rheumatoid arthritis from Jan. 2002 to Jan. 2012 to divide into TG group and OG group with 51 cases in each other. OG group were treated with methotrexate, while TG group were added folio acid on rutine therapy. The course was 2 months. Observe ESR, CRP, RF and adverse effect drier treatment of these two groups. Results The effect results in these two groups had no significant difference （P 〉0. 01 ）, but the incidence of adverse effect of TG group was lower than OG group （ P 〈0.01 ）. Conclusion Folie acid could reduce the incidence of adverse effect of methotrexate and have no effect on clinical effect. We could use these two together in clinical.