急性心肌梗死血瘀证患者纤维蛋白原、超敏C反应蛋白与补体系统表达变化

目的]探讨急性心肌梗死(AMI)血瘀证患者纤维蛋白原(FIB)、超敏C反应蛋白(hs-CRP)及补体系统表达变化。方法]检测72例AMI患者血瘀证、非血瘀证及33例健康对照者的血清样本中hs-CRP、FIB及补体C3、C4、C5b-9的表达变化,并比较以上指标之间及其与血瘀证的相关性。结果]AMI患者的血清FIB、C3、C4、C5b-9及hs-CRP表达均较对照组显著升高,且血瘀证组高于非血瘀证组;血瘀证与hs-CRP、FIB、D-2聚体水平呈正相关(r=0.239、r=0.402、r=0.199,P0.05);GRACE评分与血瘀证、hs-CRP水平呈正相关(r=0.309、r=0.376,P0.05)。结论]AMI患者具有一定程度炎性反应和补体激活,而在血瘀证中表达更为明显;血瘀证为AMI患者中的较高危者,早期辨证治疗可降低急性心血管事件的发生风险。

The expressions and changes of fibrinogen hypersensitive C reactive protein and the complement system in patients of acute myocardial infarction and blood stasis syndrome

Objective] To investigate the expression of fibrinogen hypersensitive C-reactive protein, and complement system in the patients with acute myocardial infarction and blood stasis syndrome. Methods] Detect the levels of fibrinogen, hypersensitive C reactive protein, and the complement system including C3, C4, C5b-9 for 72 patients with acute myocardial infarction including blood stasis and non-blood stasis syndrome, the same as 33 healthy control group, and analyse the correlation between the indexes above and blood stasis syndrome. Results] Comparing with the control group, levels of fibrinogen, hypersensitive C reactive protein, and the complement system including C3, C4, C5b-9 in patients of AMI were significantly higher than those in control group, and levels in blood stasis syndrome group were higher than in non-blood stasis syndrome group;there were positive correlation between blood stasis and hs-CRP, FIB and D-dimer(r=0.239, r=0.402, r=0.199, P<0.05); there were positive correlation between score of GRACE and the levels of blood stasis syndrome, hs-CRP(r=0.309, r=0.376, P<0.05). Conclusion] There are certain degree of inflammatory reaction and high coagulation state in patients with acute myocardial infarction, which express more obviously in blood stasis group;there are positive correlation between blood stasis group hs-CRP, FIB and D-dimer;early dialectical therapy for blood stasis syndrome in patients of AMI with a high risk can reduce the risk of the occurrence of acute cardiovascular events.