| 人参皂苷Re对ADP、PAF、AA诱导家兔血小板聚集功能的影响 |
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| 引用本文： | 闫海峰,代向东,樊克涛,王怡.人参皂苷Re对ADP、PAF、AA诱导家兔血小板聚集功能的影响[J].天津中医药大学学报,2016,35(5):310-313. |
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| 作者姓名： | 闫海峰 代向东 樊克涛 王怡 |
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| 作者单位： | 天津中医药大学, 天津市现代中药重点实验室, 天津 300193,天津中医药大学, 天津市现代中药重点实验室, 天津 300193,天津中医药大学, 天津市现代中药重点实验室, 天津 300193,天津中医药大学, 天津市现代中药重点实验室, 天津 300193 |
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| 基金项目： | 国家重点基础研究发展计划（“973”计划）项目资助（2012CB518404）。 |
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| 摘 要： | 目的]研究人参皂苷Re对血小板聚集功能的影响。方法]采用体外实验通过Born法观察人参皂苷Re对二磷酸腺苷钠盐(ADP)、血小板活化因子(PAF)、花生四烯酸(AA)诱导的家兔血小板聚集率的影响。结果]人参皂苷Re体外抑制ADP、PAF、AA诱导的家兔血小板聚集差异有统计学意义(P0.05,P0.01)。半数抑制浓度(IC50)分别为0.197、0.242、0.443 g/L。结论]人参皂苷Re呈剂量依赖性抑制体外ADP、PAF、AA诱导的血小板聚集,且抗ADP诱导的血小板聚集作用强于PAF、AA。
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| 关 键 词： | 人参皂苷Re 血小板聚集 二磷酸腺苷钠盐 血小板活化因子 花生四烯酸 |
| 收稿时间： | 5/7/2016 12:00:00 AM |
Effection of Ginsenoside Re on ADP, PAF, AA-induced platelet aggregation |
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| YAN Hai-feng,DAI Xiang-dong,FAN Ke-tao and WANG Yi.Effection of Ginsenoside Re on ADP, PAF, AA-induced platelet aggregation[J].Journal of Tianjin University of Traditonal Chinese Medicine,2016,35(5):310-313. |
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| Authors: | YAN Hai-feng DAI Xiang-dong FAN Ke-tao and WANG Yi |
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| Institution: | Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China,Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China,Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China and Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 300193, China |
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| Abstract: | Objective] To study the effect of ginsenoside Re on platelet aggregation function.Methods] In vitro, through the Born law, effect of ginsenoside Re on sodium salt adenosine diphosphate (ADP), platelet-activating factor (PAF), arachidonic acid (AA)-induced platelet aggregation rate of.Results] Ginsenoside Re in vitro ADP, PAF, AA-induced platelet aggregation was statistically significant difference (P<0.05, P<0.01), median inhibiting concentration (IC50), 0.197 g/L, 0.242 g/L, and 0.443 g/L respectively.Conclusion] The ginsenoside Re in a dose-dependent inhibition of in vitro ADP, PAF, AA-induced platelet aggregation, and ADP-induced platelet aggregation was stronger than PAF, AA. |
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| Keywords: | ginsenoside Re platelet aggregation ADP PAF AA |
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