心血管疾病患者高密度脂蛋白心脏保护功能的改变

高密度脂蛋白胆固醇（high density lipoprotein cholesterol，HDL-C）水平是心血管疾病风险的独立预测因素，与心血管事件发生风险呈负相关。但是单纯增加HDL-C的浓度并不能减少心血管疾病的发生率，过高浓度的HDL-C可能促进心血管疾病发生,所以HDL-C与心血管疾病发生和进展是否有因果关系仍不明确。在某些疾病内环境下，组成HDL的蛋白或脂类和参与HDL代谢的酶等成分发生改变，这些因素将导致HDL心血管保护功能下降。所以，在研究HDL与心血管疾病关系时，评估它的功能和质量，可能比评估它的数量更重要。

The changes of high density lipoprotein cardioprotection in patients with cardiovascular disease

High density lipoprotein cholesterol (HDL-C) level is an independent predictor and has an inverse relationship with incident cardiovascular events. However,the causal relation between HDL-C and atherosclerosis is uncertain. Simply to increase the levels of HDL-C can not reduced the risk of vascular events. And the cardiovascular risk increased may be associated with very high HDL-C levels. The composition of the proteins or lipid within HDL and the enzyme of HDL metabolism be changes in disease conditions,which contribute to a lower protective function of HDL. So when study relationship between HDL and cardiovascular disease, to assess its function and quality may be more important than to assess its number.