首页 | 本学科首页   官方微博 | 高级检索  
     

VEGF和抑癌基因maspin在胃癌组织中的表达及意义
引用本文:梁启廉,陈小东,王三明,李建文,黄冰,郑朝晖,陈雪松. VEGF和抑癌基因maspin在胃癌组织中的表达及意义[J]. 第三军医大学学报, 2007, 29(14): 1416-1418
作者姓名:梁启廉  陈小东  王三明  李建文  黄冰  郑朝晖  陈雪松
作者单位:广东医学院附属医院,广东医学院第一临床学院肿瘤中心,湛江,524001;广东医学院附属医院,广东医学院第一临床学院肿瘤中心,湛江,524001;广东医学院附属医院,广东医学院第一临床学院肿瘤中心,湛江,524001;广东医学院附属医院,广东医学院第一临床学院肿瘤中心,湛江,524001;广东医学院附属医院,广东医学院第一临床学院肿瘤中心,湛江,524001;广东医学院附属医院,广东医学院第一临床学院肿瘤中心,湛江,524001;广东医学院附属医院,广东医学院第一临床学院肿瘤中心,湛江,524001
摘    要:目的观察血管内皮生长因子(VEGF)和抑癌基因maspin在胃癌组织中的表达情况,研究它们与胃癌临床特征的关系。方法应用免疫组化法检测102例胃癌患者手术切除的癌组织和癌周正常组织中VEGF和maspin表达水平。结果VEGF在正常胃组织中未见表达,在胃癌组织中的表达率为50.0%,两者比较差异有显著性意义(P〈0.01)。maspin在正常胃组织中表达率为87.3%,在胃癌组织中的表达率为52.0%,两者比较差异有显著性意义(P〈0.01)。VEGF蛋白表达水平与胃癌浆膜浸润、TNM分期、淋巴结转移、5年生存率有关(P〈0.05),maspin蛋白表达水平与胃癌浆膜浸润、淋巴结转移、5年生存率有关(P〈0.05)。结论同时检测胃癌组织中VEGF与maspin表达水平,对判断胃癌浸润转移潜能及评估患者预后有一定参考价值。

关 键 词:血管内皮生长因子  maspin  胃肿瘤  免疫组织化学
文章编号:1000-5404(2007)14-1416-03
修稿时间:2006-05-302006-12-04

Expression of vascular endothelial growth factor and maspin in gastric carcinoma
LIANG Qi-lian,CHEN Xiao-dong,WANG San-ming,LI Jian-wen,HUANG Bing,ZHENG Zhao-hui,CHEN Xue-song. Expression of vascular endothelial growth factor and maspin in gastric carcinoma[J]. Acta Academiae Medicinae Militaris Tertiae, 2007, 29(14): 1416-1418
Authors:LIANG Qi-lian  CHEN Xiao-dong  WANG San-ming  LI Jian-wen  HUANG Bing  ZHENG Zhao-hui  CHEN Xue-song
Affiliation:Department of Medical Oncology, The Affiliated Hospital of Guangdong Medical College, Zhanjiang 524001, China
Abstract:Objective To study the expressions of vascular endothelial growth factor(VEGF)and maspin in gastric carcinoma and their relation to the clinicopathological features.Methods VEGF protein and maspin protein expression in 102 cases of human gastric carcinoma tissues and normal tissues around the foci were examined by immunohistochemical method(Envision).Results The overexpression rate of VEGF protein was 50.0%(51/102)in gastric carcinoma tissues and 0.0%(0/102)in normal tissues(P<0.01);as for maspin,the overexpression rate of maspin protein was 52.0%(53/102)in gastric carcinoma tissues and 87.3%(89/102)in normal tissues(P<0.01).The VEGF expressions were related to serosa invasion,TNM staging,lymph node metastasis and 5-year survival rate(P<0.05).There was a close relation of maspin expression with serosa invasion,lymph node metastasis and 5-year survival rate(P<0.05).Conclusion Detecting the protein levels of VEGF and maspin simultaneously in gastric carcinoma provide certain reference value in judging invasion and metastasis potential and evaluating the prognosis.
Keywords:vascular endothelial growth factor   maspin    gastric carcinoma   immunohistochemical method
本文献已被 CNKI 维普 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号