丙型肝炎病毒母婴传播研究

目的：探讨HCV母婴传播的可能性及其在流行病学中的意义。方法：应用ELISA方法对2136名产前检查的孕妇进行了抗－HCV检测，抗－HCV阳性者进一步应用PCR检测其HCV－RNA并收集其婴儿脐血进行抗－HCV和HCV－RNA检测。结果：孕妇的抗－HCV阳性率为1.59%(34/2136)，抗－HCV阳性母亲的HCV－RNA阳性率为47.06%(16/34)，母亲HCV－RNA阳性者发生垂直传播率为53.3%。结论 ：应用抗－HCV评价母婴传播并不合和达，只有通过检测HCV－RNA方能证实感染的存在。HCV确实存在母婴传播，但在人群HCV流行中并非主要传播途径。母新肝功能异常是影响HCV母婴传播的一个重要因素。

Study on Vertical Transmission of Hepatitis C Virus

Objective: to study the possibility of vertical transmission of hepatitis C virus and its epidemiological significance. Methods: The serum antibody of hepatitis C virus (anti HCV) in 2136 pregnant women was detected with ELISA kits . HCV RNA was detected by PCR for those who were anti HCV positive and their newborns as well. Result: The positive rate of anti HCV in pregnant women was 1.59%(34/2136). Among 34 anti HCV positive women, 16(47.06%) were HCV RNA positive. The vertical transmission rate of HCV for mothers with HCV RNA possitive was 53.3%. Conclusion: It is not appropriate to study the vertical transmission of HCV by detecting anti HCV. Detection of HCV RNA is the better method to confirm the vertical transmission. Vertical transmission is not a main route in the transmission of hepatitis C,although it exists.