肝素表面修饰可折叠亲水性丙烯酸酯人工晶状体对白内障术后炎症反应影响的评测

目的：：调查使用激光房水闪光细胞仪评测肝素表面修饰的和无肝素表面修饰的可折叠亲水性丙烯酸酯人工晶状体对前房炎症反应的影响。方法：研究组22例22眼被植入肝素表面修饰的可折叠亲水性丙烯酸酯人工晶状体,对照组21例21眼被植入无肝素表面修饰的的可折叠亲水性丙烯酸酯人工晶状体。分别在术后1、7和28d,使用激光房水闪光细胞仪检测其前房房水细胞密度和闪光数值。结果：在术后1,7d,肝素表面修饰的可折叠亲水性丙烯酸酯人工晶状体组的患者前房房水的细胞密度数值和闪光数值显著低于无肝素表面修饰人工晶状体组患者的检测数值。在术后28d,两者间细胞密度数值和闪光数值无明显差别。结论：肝素表面修饰的可折叠亲水性丙烯酸酯人工晶状体与无肝素表面修饰人工晶状体相比,可以降低白内障术后早期炎症反应。激光房水闪光细胞仪可以安全、客观地评测前房炎症反应。

Objective assessment of the inflammatory reaction in foldable heparin surface-modified hydrophilic acrylic intraocular lens

AIM: To investigate the inflammatory reaction in the anterior chamber after cataract surgery for the heparin surface modified foldable hydrophilic acrylic intraocular lens(HSM-IOL)by laser flare-cell meter.

METHODS: The test group consisted of 22 patients(22 eyes)in whom a HSM-IOL was implanted in the capsular bag(HSM-IOL group). There was one control group including 21 patients(21 eyes)who received a normal foldable hydrophilic acrylic IOL(uncoated IOL group). Anterior chamber flare and cell values were measured, using laser flare-cell meter preoperatively and 1, 7, 28d postoperatively.

RESULTS: In the HSM-IOL group, the flare and the cells values were significantly lower than those in the uncoated IOL group 1d and 7d postoperatively. Between the two groups, there were no significant differences in cells and the level of flare on the 28d postoperative.

CONCLUSION: HSM-IOL can decrease inflammation in early postoperative stage, compared with the uncoated IOL. The laser flare-cell meter provides a safe and objective technique for measuring inflammation in anterior chamber.