三种超促排卵方案的临床应用效果分析

目的比较三种控制性超促排卵（COH）方案在体外受精-胚胎移植（IVF-ET）/卵胞浆内单精子注射（ICSI）的临床结果,分析人尿绝经期促性腺激素（HMG）和基因重组促性腺激素（rFSH）的应用价值.方法回顾性分析570例接受IVF-ET /ICSI的不育患者,采用三种COH方案的情况.A组50个周期,应用HMG;B组81个周期,应用rFSH;C组445个周期,rFSH结合HMG促排卵.结果 B组用药天数少于A组 （P〈 0.05）,用药安瓿数少于A组和C组,有统计学差异（P〈 0.05）;B组获卵数明显多于A组和C组（P〈 0.01, P〈 0.05）.结论 COH中应用rFSH可以募集较多的卵泡,三种COH方案的胚胎发育情况、临床妊娠率、胚胎移植结局无显著差异.

A retrospective analyze of three kinds of tropichyperovulation programme: ovarian response and clinical outcomes

Objective To compare the clinical outcome of three kinds of controlled ovarian hyper stmulation programe in women umdergoing in-vitro fertilization (IVF-ET) / intracytoplasmic sperm injection (ICSI) .Methods Clinical data of 570 infertile women(576 cycles) after IVF-ET / ICSI were analyzed retrospectively Following down regulation in a long gonadotrophin-releasing hormone(GnRH) agonist protocal , patients received three different tropichyperovulation programme according ecanomic situation and ovarian response . Group A 50 cycles , only with HMG ; Group B 81 cycles , only with Gonal-F ; Group C 445 cycles , mixed Gonal-F with HMG .Results The duration of Gn treatment was significantly shorter in group B than group A (P<0.05) . The numbers of anpoules in groups B was significantly less than group A and group C (P<0.05) . And there were significantly more follicles and more oocytes retrieved in group B than in group A and group C (P<0.01, P <0.05).Conclusion Although there were significantly more follicles and more oocytes retrieved in group B .There was no significant difference in the rates of implantation and pregnancy among three groups .