| 慢性髓性白血病的危险因素探讨 |
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| 引用本文： | 陈珊珊 张海帆. 慢性髓性白血病的危险因素探讨[J]. 临床血液学杂志, 1993, 6(3): 112-114 |
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| 作者姓名： | 陈珊珊 张海帆 |
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| 作者单位： | 北京医科大学血液病研究所 100044(陈珊珊，张海帆，薛文韬，李鲲，王佩)，北京医科大学血液病研究所 100044(刘扬) |
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| 摘 要： | 对38例不同病期的慢性髓性白血病患者骨髓进行DNA链损伤(%D值)、DNA-非整倍体及流式细胞仪细胞膜抗原CD15与HLA-DR测定。结果显示三种参数能较可靠地预示病情进展。DNA-非整倍体的存在及DNA链损伤加重,均为CML急变的高危指标。CD15与HLA-DR比值测定简易可靠。其比值倒置先于细胞形态学的恶化,应定期追踪复查。
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| 关 键 词： | 白血病 CML DNA链损伤 髓性 |
Predictors for Prognosis of Chronic Myelocytic Leukemia |
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| Chen Shanshan,Zhang Haifan,Xue Wentao,et al Institute of Hematology,Beijing Medical University. Predictors for Prognosis of Chronic Myelocytic Leukemia[J]. Journal of Clinical Hematology, 1993, 6(3): 112-114 |
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| Authors: | Chen Shanshan Zhang Haifan Xue Wentao et al Institute of Hematology Beijing Medical University |
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| Abstract: | Bone marrows from 30 newly diagnosed Ph~+ CML(21 in chronicphase, CML-CP; 9 in accelerate phase, CML-AP) and 8 followed up patients in blastcrisis(CML-BC) were tested by DNA strand breaks (%D value), DNA-aneuploidy,flow cytometry-cell surface antigen expression for CD_(15) and HLA-DR ratio. Our re-sullts showed that all these three parameters changed as the disease escalated. A verylow value of %D and DNA-aneuploidy occurence were high risk factors. CD_(15) andHLA-DR measurement was simple and reliable. The ratio<1.0 appeared earlier thanmorphology changing in CML-AP and should be followed up regularly. |
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| Keywords: | Chronic myelocytic leukemia(CML) DNA strand break DNA aneuploidy CD15 and HLA-DR ratio |
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