Familial paroxysmal exercise-induced dyskinesia and benign epilepsy: a clinical and neurophysiological study of an uncommon disorder |
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Authors: | L. Margari T. Perniola G. Illiceto E. Ferrannini M.G. De Iaco A. Presicci R. Santostasi P. Ventura |
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Affiliation: | (1) Department of Neurological and Psychiatric Sciences, Child Neuropsychiatric Service, University of Bari, Piazza Giulio Cesare, I-70124 Bari, Italy, IT |
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Abstract: | We report a family with 6 members affected by a long-lasting paroxysmal exertion-induced dyskinesia. Fasting and stress were precipitating factors. All the patients of this family had also epileptic seizures mainly of generalised type with a favourable outcome. All patients were submitted to a neurophysiological study which included somatosensory evoked potentials by median nerve stimulation (MN-SEPs), somatosensory evoked potentials by posterior tibial nerve stimulation (PTN-SEPs), brainstem auditory evoked potentials (BAEPs), visual evoked potentials (VEPs), motor evoked potentials (MEPs) by magnetic transcranial cortical stimulation (TCS) and electromyography (EMG). The neurophysiological findings suggest a hyperexcitability at the muscular and brain membrane levels, probably due to an ion channel disorder. Received: 2 February 2000 / Accepted in revised form: 16 June 2000 |
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Keywords: | Familial paroxysmal dyskinesia Epilepsy Evoked potentials Electromyography |
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