| OXA-23酶介导的鲍氏不动杆菌对碳青霉烯的耐药机制 |
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| 引用本文： | 钱洁,宋诗铎. OXA-23酶介导的鲍氏不动杆菌对碳青霉烯的耐药机制[J]. 国外医药(抗生素分册), 2007, 28(3): 121-123,134 |
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| 作者姓名： | 钱洁 宋诗铎 |
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| 作者单位： | 天津医科大学第二医院,天津,300211;天津医科大学第二医院,天津,300211 |
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| 摘 要： | OXA-23酶是第一个从鲍氏不动杆菌中分离出来的D类碳青霉烯酶,blaOXA-23基因位于质粒或者染色体上.本文主要对鲍氏不动杆菌中OXA-23酶介导的对碳青霉烯类抗生素的耐药机制进行综述,并对编码OXA-23酶基因的结构、遗传背景及流行状况进行总结.
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| 关 键 词： | 鲍氏不动杆菌 碳青霉烯酶 插入序列 |
| 文章编号： | 1001-8751（2007）03-0121-03 |
| 修稿时间： | 2006-06-30 |
Mechanism of Carbapenem-resistance Induced by OXA-23 in Acinetobacter baumannii |
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| QIAN Jie,SONG Shi-duo. Mechanism of Carbapenem-resistance Induced by OXA-23 in Acinetobacter baumannii[J]. world notes on antibiotics, 2007, 28(3): 121-123,134 |
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| Authors: | QIAN Jie SONG Shi-duo |
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| Affiliation: | The Second Affiliated Hospital, Tianjin Medical University, Tianjin 300211, China |
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| Abstract: | OXA-23 is a carbapenemase of class D that was first isolated from a clinical isolate of Acinetobacter bauamnnii. The gene encoding OXA-23 is located in chromosome or plasmid. In this review, the mechanism of carbapenem-resistance induced by OXA-23 in Acinetobacter baumannii was described. In addition, structure, genetic background and prevalence of the gene encoding OXA-23 were also discussed. |
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| Keywords: | Acinetobacter baumannii carbapenemase insertion sequence |
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