| 多药耐药基因表达检测在白血病治疗中的应用研究 |
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| 引用本文： | 杨建峰,秦良宜,刘惠杰. 多药耐药基因表达检测在白血病治疗中的应用研究[J]. 白血病．淋巴瘤, 2001, 10(2): 95-97 |
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| 作者姓名： | 杨建峰 秦良宜 刘惠杰 |
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| 作者单位： | 江苏省连云港市第一人民医院,江苏,连云港,222002 |
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| 摘 要： | 目的：研究MDR1基因表达与白血病化疗疗效的关系。方法：应用反转录聚合酶链反应（RT－PCR）技术对32例临床标本和10例正常人进行了MDR1基因表达检测，并结合患者对化疗药物的敏感性及化疗效果进行比较分析。结果：在白血病患者中MDR1基因表达量越高，。耐药性越强，疗效越差，且复发患者MDR1基因表达明显高于初发患者，结论：MDR1介导的耐药是白血病多药耐药的主要机制，与白血病化疗药物的敏感性有较好的相关性，对指导白血病化疗效果评价具有良好的应用前景。
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| 关 键 词： | MDR1 化疗 白血病 治疗 |
| 文章编号： | 1009-9921(2001)02-0095-03 |
| 修稿时间： | 2000-03-06 |
STUDY OF MDR1 IN CHEMOTHERAPY OF ACUTE LEUKEMIAS |
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| YANG Jian-fen,QIN Liang-yi,LIU Hui-jie. STUDY OF MDR1 IN CHEMOTHERAPY OF ACUTE LEUKEMIAS[J]. Journal of Leukemia & Lymphoma, 2001, 10(2): 95-97 |
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| Authors: | YANG Jian-fen QIN Liang-yi LIU Hui-jie |
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| Abstract: | Objective:To investigate the relationship between MDR1 gene expression and the effect of chemotherapy in acute leukemia.Methods:The MDR1 gene of 32 clinical samples and 10 normal samples was detected with RT-RCR.The relationship between MDR1 gene expression and sensitivty of patients to chemotherapy medicines was evaluated.Results:The stronger the resistance was the worse the effects would be and the higher of MDR1 in relapsed patients.Conclusion:The resistance induced by MDR1 is the main mechanism of multidrug resistance in acute leukemia.MDR1 is promising in derecting chemotherapy and evaluating the effect of chemotherapy. |
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| Keywords: | Multidrug resistance Chemotherapy Acute leukemia |
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