| Smac／DIABLO与消化系统肿瘤关系的研究进展 |
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| 引用本文： | 李淑芹,关景明. Smac／DIABLO与消化系统肿瘤关系的研究进展[J]. 胃肠病学和肝病学杂志, 2011, 20(12): 1157-1159 |
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| 作者姓名： | 李淑芹 关景明 |
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| 作者单位： | 哈尔滨医科大学附属第二医院消化科,黑龙江哈尔滨,150086 |
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| 摘 要： | Smac/DIABLO （the second mitochondrial activator of caspase/direct IAP binding protein with low pI）是一种新发现的线粒体蛋白，在细胞发生凋亡时，与细胞色素c一起被线粒体释放到胞质中，与IAPs结合，解除IAPs对caspase的抑制，从而诱导细胞凋亡。Smac这种促凋亡作用对消化系统肿瘤的发生、发展以及肿瘤的治疗具有重要意义。
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| 关 键 词： | Smac 细胞凋亡 消化系统肿瘤 |
Relationship between Smac/DIABLO and digestive system tumors |
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| LI Shuqin , GUAN Jingming. Relationship between Smac/DIABLO and digestive system tumors[J]. Chinese Journal of Gastroenterology and Hepatology, 2011, 20(12): 1157-1159 |
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| Authors: | LI Shuqin GUAN Jingming |
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| Affiliation: | LI Shuqin,GUAN JingmingDepartment of Gastroenterology,the Second Affiliated Hospital of Harbin Medical University,Harbin 150086,China |
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| Abstract: | Smac/DIABLO(the second mitochondrial activator of caspase/direct IAP binding protein with low pI) is a new found mitochondrial protein that is released to the cytosol with cytochrome c when a cell is triggered to undergo programmed cell death.It promotes apoptosis through its ability to adhere to IAPs,inhibiting their caspase-binding activity. |
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| Keywords: | Smac Apoptosis Digestive system tumors |
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