| P53、Ki-67、Bcl-2、EGFR与鼻咽癌放射敏感性的相关性研究 |
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| 引用本文： | 敖帆 廖瑜露. P53、Ki-67、Bcl-2、EGFR与鼻咽癌放射敏感性的相关性研究[J]. 实用中西医结合临床, 2010, 10(4): 4-5. DOI: 10.3969/j.issn.1671-4040.2010.04.002 |
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| 作者姓名： | 敖帆 廖瑜露 |
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| 作者单位： | 江西省肿瘤医院,南昌,330029 |
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| 基金项目： | 江西省卫生厅科研基金资助项目 |
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| 摘 要： | 目的:分析鼻咽癌组织中P53、Ki-67、Bcl-2、EGFR的表达与鼻咽癌患者放射敏感性的相关性。方法:应用免疫组化方法检测200例放疗前鼻咽活检组织中P53、Ki-67、Bcl-2、EGFR的表达。结果:200例鼻咽癌组织中,Bcl-2和EGFR的表达与鼻咽癌放射敏感性成负相关(P<0.05),Ki-67的表达与放射敏感性成正相关(P<0.05),P53与放疗敏感性无关(P>0.05)。结论:Bcl-2、Ki-67和EGFR的表达可以反映鼻咽癌放射敏感性,可做为预测鼻咽癌放疗效果的重要指标,而P53则不能预测放疗敏感性。
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| 关 键 词： | 鼻咽癌 P53 Ki-67 Bcl-2 EGFR 放疗敏感性 |
Association between the Expression of P53,Ki-67,Bcl-2 and EGFR and the Radiosensitivity of Nasopharyngeal Cancer |
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| Ao Fan,Liao Yu-lu. Association between the Expression of P53,Ki-67,Bcl-2 and EGFR and the Radiosensitivity of Nasopharyngeal Cancer[J]. Practical Clinical Journal of Integrated Traditional Chinese and Western Medicine, 2010, 10(4): 4-5. DOI: 10.3969/j.issn.1671-4040.2010.04.002 |
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| Authors: | Ao Fan Liao Yu-lu |
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| Affiliation: | Ao Fan,Liao Yu-lu |
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| Abstract: | Objective:To explore the association between the expression of P53,Ki-67,Bcl-2 and EGFR and the radiosensitivity of nasopharyngeal cancer.Methods:Using immunohistochemistry,the expression of P53,Ki-67,Bcl-2 and EGFR were evaluated on tumor tissues from 200 nasopharyngeal cancer patients.Results:A statistically significant correlation was observed between overexpression of Bcl-2 and EGFR and radioresistance(P<0.05).Ki-67 positivity was significantly associated with radiosensitivity(P<0.05).The expression of ... |
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| Keywords: | P53 Ki-67 Bcl-2 EGFR |
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