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| 意向运动疗法对大鼠局灶性脑缺血后GFAP和SYP表达的影响 | |
| 引用本文： | Hou DR,Shawuti S,Liu JF,Zhu HX,Deng JF,Hu ZY,Zhou J,Liu YX. 意向运动疗法对大鼠局灶性脑缺血后GFAP和SYP表达的影响[J]. 南方医科大学学报, 2011, 31(9): 1543-1546 |
| 作者姓名： | Hou DR Shawuti S Liu JF Zhu HX Deng JF Hu ZY Zhou J Liu YX |
| 作者单位： | 1. 中南大学湘雅三医院 神经内科,湖南长沙,410013 2. 新疆医科大学附属中医医院脑病一科,新疆乌鲁木齐,830000 3. 中南大学湘雅三医院 中心实验室,湖南长沙,410013 |
| 基金项目： | 湖南省科技厅项目(2010SK3110,2011FJ3206) |
| 摘 要： | 目的探讨意向运动疗法对大鼠局灶性脑缺血2 h后再灌注缺血周围脑组织GFAP和SYP表达的影响及其对神经再生修复作用的可能机制。方法采用线栓法建立(middle cerebral artery occlusion,MCAO)大鼠模型,缺血2 h后进行再灌注;再灌注24 h后根据Longa神经功能缺损评分选择实验模型,随机分为模型组(MCAO组)、环境改变组(environmental modification,EM)、意向运动组(willed movement,WM),每组再分为3、7、15 d三个亚组;大鼠处死前再进行Longa评分;通过免疫组织化学及免疫荧光观察缺血周围脑组织GFAP和SYP的表达。结果再灌注15 d时,WM组大鼠神经功能缺损评分低于MCAO组、EM组(P<0.05);再灌注7、15 d时,WM组大鼠GFAP和SYP的表达量均高于MCAO组、EM组(P<0.05);MCAO组与EM组比较:任一时间点的GFAP和SYP表达均无统计学差异(P>0.05)。结论意向运动疗法促进了MCAO大鼠神经功能缺损的恢复;可能与其促进缺血周围脑组织GFAP和SYP的表达有关。 |
| 关 键 词： | 意向运动 脑缺血 胶质纤维酸性蛋白 突触素 |
Effect of willed movement therapy on GFAP and SYP expression in rats with cerebral ischemia-reperfusion |
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| Hou De-ren,Shawuti Shadike,Liu Jian-feng,Zhu Hai-xia,Deng Jin-feng,Hu Zhong-yang,Zhou Jun,Liu Yuan-xin. Effect of willed movement therapy on GFAP and SYP expression in rats with cerebral ischemia-reperfusion[J]. Journal of Southern Medical University, 2011, 31(9): 1543-1546 | |
| Authors: | Hou De-ren Shawuti Shadike Liu Jian-feng Zhu Hai-xia Deng Jin-feng Hu Zhong-yang Zhou Jun Liu Yuan-xin |
| Affiliation: | HOU De-ren1,Shadike·Shawuti2,LIU Jian-feng1,ZHU Hai-xia1,DENG Jin-feng1,HU Zhong-yang1,ZHOU Jun3,LIU Yuan-xin2 1Department of Neurology,3Laboratory Center,Third Xiangya Hospital,Central South University,Changsha 410013,China,2Department of Encephalopathy,Traditional Chinese Medicine Hospital of Xinjiang Medical University,Urumqi 830000 |
| Abstract: | Objective To determine the effect of willed movement on the expression of glial fibrillary acidic protein(GFAP) and synaptophysin(SYP) in adult rats with cerebral ischemia-reperfusion,and explore the mechanism of willed movement in promoting nerve repair and regeneration.Methods Adult rat models of cerebral ischemia-reperfusion injury were established by middle cerebral artery occlusion(MCAO) for 2 h followed by a 24-h reperfusion.The models were then divided randomly into 3 groups,namely the model group,en... |
| Keywords: | willed movement cerebral ischemia glial fibrillary acidic protein synaptophysin |
| 本文献已被 CNKI 万方数据 PubMed 等数据库收录！ | |