Ultrasound Mediated Transdermal Insulin Delivery in Pigs Using a Lightweight Transducer |
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Authors: | E J Park Jacob Werner Nadine Barrie Smith |
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Institution: | (1) Department of Bioengineering, Pennsylvania State University, University Park, Pennsylvania, USA;(2) Animal Resource Program, Pennsylvania State University, University Park, Pennsylvania, USA;(3) Graduate Program in Acoustics, Pennsylvania State University, University Park, Pennsylvania, USA |
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Abstract: | Purpose In previous studies, ultrasound mediated transdermal drug delivery has shown a promising potential as a method for noninvasive
drug administration. For prospective future human application, this study was designed to determine the feasibility of lightweight
cymbal transducer array as a practical device for noninvasive transdermal insulin delivery in large pigs.
Materials and Methods Six Yorkshire pigs (100–140 lbs) were divided into two groups. As the control (n = 3), the first group did not receive any ultrasound exposure with the insulin. The second group (n = 3) was treated with ultrasound and insulin at 20 kHz with an Isptp = 100 mW/cm2 at a 20% duty cycle for 60 min. With the pigs in lateral recumbency after anesthesia, the ultrasound transducer with insulin
was placed on the axillary area of the pig. At the beginning and every 15 min up to 90 min, the blood glucose level was determined
using a glucose monitoring system. To compare the results of individual animals, the change of blood glucose level was normalized
to each animal’s initial glucose value at the start of the experiment.
Results Although each animal had a different initial glucose level, the mean and standard error for the six animals was 146 ± 13 mg/dl.
For the control group, the blood glucose level increased to 31 ± 21 mg/dl compared to the initial baseline over the 90 min
experiment. However for the ultrasound with insulin treated group, the glucose level decreased to −72 ± 5 mg/dl at 60 min
(p < 0.05) and continued to decrease to −91 ± 23 mg/dl in 90 min (p < 0.05).
Conclusion The results indicate the feasibility of ultrasound mediated transdermal insulin delivery using the cymbal transducer array
in animal with a similar size and weight to a human. Based on these result, the cymbal array has potential as a practical
ultrasound system for noninvasive transdermal insulin delivery for diabetes management. |
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Keywords: | diabetes drug delivery insulin transducer ultrasound |
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