Incompatibility of indometacin and benzalkonium in eye drops due to ion-pair formation |
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| Authors: | S M Dreijer-Van der Glas and A Bult |
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| Institution: | (1) Department of Pharmaceutical Analysis, Subfaculty of Pharmacy, State University of Utrecht, Catharijnesingel 60, 3511 GH Utrecht, The Netherlands |
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| Abstract: | Eye drop formulations containing indometacin and benzalkonium salt often show an opalescence as a result of ion-pair formation. The insoluble ion pair was isolated and characterized by infrared and ultraviolet spectroscopy and thin layer chromatography. This ion pair is also responsible for the bad assay results of benzalkonium using the ion-pair extraction method with bromothymol blue as counterion. The distribution |
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| Keywords: | Indometacin Benzalkonium Ion pair Incompatibility |
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