IL-10-1082位基因多态性与甘肃地区HBV感染的相关性研究

研究IL-10-1082基因多态性与甘肃地区HBV感染的关系.选择汉族慢性乙型肝炎156例及88例正常对照,采用等位基因特异引物聚合酶链反应(ASPCR)方法,分析甘肃地区IL-10-1082启动子基因多态性.结果发现IL-10-1082位各基因型频率在HBV感染者中和在健康对照者中的差异无显著性.对抗病毒治疗应答组与无应答组基因型频率相比差异有显著性,对抗病毒治疗的反应与G等位基因有一定的相关性.HBV DNA定量中高载量组与低载量组IL-10-1082位基因型频率及等位基因频率相比,差异均无显著性.结论为甘肃地区HBV感染者IL-10-1082位基因多态性与对抗病毒治疗的反应有一定相关性.

Genetic association of interleukin(IL) - 10 polymorphisms with hepatitis B in Gansu province

To study the association between patients with HBV in Gansu province and the polymorphisms in promoter region of the IL- 10 gene at position- 1082.We have investigated two candidate gene loci in 156 patients with HBV infection and 80 healthy controls.The polymorphisms were assessed by the ASPCR (allele- specific polymerase chain reaction) .We didn't find the difference in the IL- 10 gene at position- 1082 genetype distributions between patients with chronic HBV infection and controls.There is also no difference in groups with different ALT level. But there is difference in gronps with different antiviral therapy. G allele was associated with the response to antiviral therapy. There is no difference in groups with different HBV DNA loading. Conclusion is the polymorphisms in promoter region of the IL - 10 gene at position - 1082 was associated with the response to antiviral therapy in the patients with HBV infection.