冠状动脉粥样硬化性心脏病直接支架置入时腺苷的心肌保护作用

目的探讨冠状动脉内注入腺苷在直接支架置入术中的心肌保护作用。方法27例适合直接支架置入术的冠心病患者，随机分为对照组（14例）与腺苷组13例。将生理盐水10rnl或腺苷300μg 1min内经过左或右冠状动脉口注入相应病变动脉，之后直接置入支架。测定2纽患者在支架置入前及1h后的血清磷酸肌酸激酶（CK）及其同功酶（CK—MB）、肌钙蛋白Ⅰ（CTnI的峰值。结果对照组术前与术后比较、腺苷组术前与术后比较、2组间术前、术后比较，各项心肌损伤标志物均无统计学意义（P〉0．05）。结论腺苷冠脉内注射不能减轻直接支架置入时的心肌微损伤。

The myocardial protective effect of adenosine during direct stenting in patients with coronary artery disease

Objective To investigate the myocardial protective effect of intracoronary adenosine infusion during direct stent implantation in patients with coronary artery disease. Methods 27 patients with coronary artery disease who was suitable for the direct stenting were randomly divided into saline group（control group, n = 14） and adenosine group （ n = 13）. The direct stenting was finished after the injection of saline or adenosine（300μg） into the infaret-related artery through the opening of the right or left coronary artery within 1 minute. Serum levels of the peak of CK, CK-MB, cTnI in vein blood were measured 1 hour before and after stenting operation. Results There was no signitleant difference between pre-stenting and post-stenting in both groups. Conclusion There is no effect in intraeoronary adenosine infusion on minor myocardial injury during direct stenting.