| 240例癫痫患儿丙戊酸钠的血药浓度监测 |
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| 引用本文： | 李红健,曹丽蒙,刘文丽. 240例癫痫患儿丙戊酸钠的血药浓度监测[J]. 中国药房, 2007, 18(20): 1561-1562 |
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| 作者姓名： | 李红健 曹丽蒙 刘文丽 |
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| 作者单位： | 新疆自治区人民医院临床药学研究所,乌鲁木齐市830001 |
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| 摘 要： | 目的:监测癫痫患儿丙戊酸钠的血药浓度。方法:采用荧光偏振免疫法测定240例癫痫患儿的血药浓度并分析结果。结果:癫痫患儿丙戊酸钠血药浓度<50μg·mL-1的有69例/次(占28.75%),在50~100μg·mL-1之间的有153例/次(占63.75%),>100μg·mL-1的有18例/次(占7.50%)。结论:患儿血药浓度个体差异大,丙戊酸钠血药浓度监测对临床合理用药有重要的指导作用,应根据血药浓度个体化用药。
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| 关 键 词： | 癫痫患儿 丙戊酸钠 血药浓度 监测 个体化给药 |
| 文章编号： | 1001-0408（2007）20-1561-02 |
| 收稿时间： | 2006-11-30 |
| 修稿时间： | 2006-11-302007-04-19 |
Serum Concentration of Valproate Sodium:Analysis of 240 Epileptic Children |
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| LI Hongjian,CAO Limeng,LIU Wenli. Serum Concentration of Valproate Sodium:Analysis of 240 Epileptic Children[J]. China Pharmacy, 2007, 18(20): 1561-1562 |
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| Authors: | LI Hongjian CAO Limeng LIU Wenli |
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| Abstract: | OBJECTIVE:To monitor the serum concentration of valproate sodium in epileptic children.METHODS:The serum concentration of valproate sodium in 240 epileptic children patients were determined by fluorescence polarization immunoassay and the determination results were analyzed.RESULTS:Of the total 240 cases,69 (28.75%) were <50μg·mL-1,153(63.75%) were with the range of 50～100μg·mL-1 and 18(7.50%) were >100μg·mL-1 in serum concentration of valpr-oate sodium.CONCLUSION:There are great individual differences among patients in serum concentration of valproate sodium.Monitoring of the serum concentration of valproate sodium is of great importance in guiding reasonable clinical drug use.It is advisable to adopt individualized administration scheme according to serum drug concentration. |
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| Keywords: | Epileptic children Valproate sodium Serum concentration Monitoring Individualized administration |
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