Pancreatitis and altered glucose tolerance in mice infected with coxsackie B4 virus

Summary CD₁ mice infected with Coxsackie B₄ virus showed an early polymorph infiltration of the pancreas, which later changed to a mononuclear exudate. A state of glucose intolerance developed concurrently and both events coincided with the inhibition of migration of spleen cells in the presence of the virus. The relevance of these findings to human juvenile-onset diabetes mellitus is discussed.