预注异丙嗪对小鼠足底皮下注射甲醛的超前镇痛效应

目的研究异丙嗪是否具有超前镇痛作用。方法将小鼠按分层随机区组设计分成3组：异丙嗪（5mg.kg-1）＋哌替啶（20 mg.kg-1）组（P＋D组）、哌替啶（40 mg.kg-1）组（D组）、生理盐水组（NS组）,每组10只。以甲醛法分别观察各组小鼠注射甲醛后5 min内的舔足时间。结果 P＋D组和D组小鼠舔足时间均显著低于NS组（P〈0.01）,而两组间的差异无统计学意义（P〉0.05）。结论异丙嗪具有超前镇痛作用。

Preemptive analgesic effects of pre-injection of promethazine on the nociception induced by subcutaneous injection of formalin in the sole of mouse paw

Objective To investigate whether promethazine has the effect of preemptive analgesia.Methods 30 mice were divided into three groups by stratified random block design（n=10,each）： promethazine（5 mg·kg-1） ＋ pethidine（20 mg·kg-1） group（P＋D group）,pethidine（40 mg·kg-1） group（D group） and normal saline group（NS group）.In the formalin test,subcutaneous injection of formalin was administered in the sole of mouse paw and the duration of paw-licking within 5 min was observed in each mouse.Result The duration of paw-licking was shorter in P＋D group or D group than in the NS group（P0.01）,while there was no statistical difference between P＋D group and D group（P0.05）.Conclusion Promethazine has the effect of preemptive analgesia.