Human amniotic fluid α-glucosidase |
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| Authors: | Livia Poenaru Marie-Claude Vinet Jean-Claude Dreyfus |
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| Institution: | 1. Department of Biochemistry C, Panum Institute, University of Copenhagen Denmark;2. Medical-gastroenterological Department C, Herlev University Hospital Denmark;3. Pediatric Department L and Medical Department F, Gentofte University Hospital, Copenhagen Denmark |
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| Abstract: | Amniotic fluid in midpregnancy contains significant α-glucosidase activity. This enzyme is distinguishable from the lysosomal acid α-glucosidase, deficiency of which is associated with Pompe's disease.The two enzymes differ in optimum pH, thermal stability, electrophoretic migration, isoelectric point, molecular mass, and immunological response. Amniotic α-glucosidase is also different from the classical neutral form.Immuno-cross reactions suggest that the amniotic fluid enzyme has a double fetal origin: renal and intestinal. It seems that α-glucosidase in amniotic fluid is linked to lipids. |
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| Keywords: | Correspondence should be addressed to J -C Dreyfus Institut de Pathologie Moléculaire 24 rue du Faubourg St Jacques 75014 Paris France |
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