α-l-Fucosidase m cystic fibrosis: analysis of skin fibroblasts and liver |
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Authors: | Ann Harris Dallas Swallow |
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Institution: | 1. Paediatric Research Unit, The Prince Philip Research Laboratories, Guy''s Hospital Medical School, London SE1 9RT U.K.;2. MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College, LondonU.K. |
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Abstract: | The lysosomal enzyme α-l-fucosidase has been examined by thin layer gel and column isoelectric focusing in skin fibroblasts and liver from patients with cystic fibrosis and controls. All three common phenotypes of the enzyme were observed in both control and CF fibroblasts. When individuals of the same α-l-fucosidase phenotype were compared, no major differences between the isozyme profiles of cystic fibrosis patients and controls were detected in either fibroblasts or liver tissue. |
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Keywords: | To whom correspondence should be addressed |
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