The use of concanavalin a crossed immuno-affinoelectrophoresis to detect hormone-associated variations in α1-acid glycoprotein |
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Authors: | Christine Wells TC Bøjg-Hansen EH Cooper MR Glass |
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Institution: | 1. The Unit for Cancer Research, University of Leeds, Leeds U.K.;2. The Protein Laboratory, University of Copenhagen Denmark;3. The Department of Obstetrics and Gynaecology, University of Leeds, Leeds U.K. |
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Abstract: | α1-Acid glycoprotein produces three peaks on crossed immuno-affinoelectrophoresis with concanavalin A in the first dimension, which is indicative of a degree of heterogeneity in the carbohydrate portion of this plasma glycoprotein. A different pattern, however, showing relatively less concanavalin A-binding material, is found in association with and after an increase in female sex hormone levels. Our observations strongly suggest a prolonged hormonal effect on the carbohydrate composition of a1-acid glycoprotein, which may alter the metabolism or the function of the protein. |
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Keywords: | To whom correspondence should be addressed |
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