| 注射用硫酸奈替米星处方及工艺的研究 |
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| 引用本文： | 施劲松,李幸苗. 注射用硫酸奈替米星处方及工艺的研究[J]. 中国新药杂志, 2005, 14(9): 1155-1156 |
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| 作者姓名： | 施劲松 李幸苗 |
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| 作者单位： | 浙江省永康市第一人民医院药剂科,永康,321300 |
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| 摘 要： | 目的:研究注射用硫酸奈替米星最佳处方和工艺.方法:硫酸奈替米星分别加各种抗氧剂以相同工艺制备冻干粉,以分光光度法测分解产物吸收度,以微生物检定法测效价;通过测共熔点和绘制冻干曲线进行冻干工艺筛选.结果和结论:以亚硫酸钠为抗氧剂的处方在430 nm处的吸收度最小,效价最高;以速冻法制备成品效果较好.
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| 关 键 词： | 硫酸奈替米星 处方筛选 工艺筛选 |
| 文章编号： | 1003-3734（2005）09-1155-02 |
| 收稿时间： | 2004-04-26 |
| 修稿时间： | 2004-04-26 |
Evaluation of netilmicin sulfate for injection: formulation and preparation |
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| SHI Jin-song,LI Xing-miao. Evaluation of netilmicin sulfate for injection: formulation and preparation[J]. Chinese Journal of New Drugs, 2005, 14(9): 1155-1156 |
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| Authors: | SHI Jin-song LI Xing-miao |
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| Abstract: | Objective:To optimize the formulation and preparation of netilmicin sulfate for injection.Methods:The freeze-dried powders of netilmicin sulfate containing varieties of anti-oxidants were prepared by a uniform procedure.The optimal formulation was selected based on quantity of degradation product (determined by spectrophotometry),the titer (determined by microbiological assay),and the characteristics of freeze-dried plot showing co-melting points versus freeze-dried temperature.Result and Conclusion:The formulation containing sodium sulfite showed the minimal degradation products and maximal titer.The freeze-dried preparation may produce the better quality of netilmicin sulfate for injection. |
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| Keywords: | netilmicin sulfate for injection optimal formulation optimal preparation |
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