| 摘 要： | AIM:To investigate the expression of vascular endothelial growth factor-C(VEGF-C)and the relationship between VEGF- C and lymphangiogenesis,lymph node metastasis in colorectal cancer. METHODS:Fifty six cases of colorectal cancer were selected randomly.Expression of VEGF-C was detected by immuno- histochemistry,and lymphatic vessels were stained by enzyme histochemical method. RESULTS:VEGF-C expression was found in 66.7%(37/56) patients.In VEGF-C positive and negative patients,the lymphatic vessel density was 25.16±7.52 and 17.14±7.22, respectively(P<0.05).The rate of lymph node metastasis in VEGF-C positive patients(81.1%)was significantly higher than that in the negative group(42.1%). CONCLUSION:VEGF-C expression may induce lymphangi- ogenesis in colorectal cancer,as a result,tumor cells can entry the lymphatic vessels easily.VEGF-C may serve as a useful prognotic factor in colorectal carcinoma.
|
