| 夫西地酸在含果糖氯化钠溶液中的配伍稳定性考察 |
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| 引用本文： | 李雪松,钱斌,杨龙,李小军,晏远志,邹顺.夫西地酸在含果糖氯化钠溶液中的配伍稳定性考察[J].中国药业,2009,18(12):22-23. |
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| 作者姓名： | 李雪松 钱斌 杨龙 李小军 晏远志 邹顺 |
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| 作者单位： | 昆明医学院第一附属医院药剂科,云南,昆明,650032 |
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| 摘 要： | 目的考察夫西地酸在含果糖的0．9％氯化钠注射液中的稳定性。方法观察夫西地酸与果糖在氯化钠溶液中配伍后室温放置6h内的外观并测定pH，采用高效液相色谱（HPLC）法测定配伍液室温放置6h内夫西地酸的含量变化。结果与配伍0h比较，配伍液放置6h内的外观、色泽均无明显变化，pH略有变化；配伍液中夫西地酸含量无明显变化，均保持在95％以上，配伍6h内无新物质产生。结论夫西地酸与果糖在氯化钠溶液中配伍后室温放置6h内夫西地酸性质基本稳定。
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| 关 键 词： | 夫西地酸 果糖 配伍 稳定性 |
Investigation of Compatible Stability of Fusidate Sodium for Injection in 0.9% Sodium Chloride Injection Containing Fructose Sodium |
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| Li Xuesong,Qian Bin,Yang Long,Li Xiaojun,Yan Yuanzhi,Zou Shun.Investigation of Compatible Stability of Fusidate Sodium for Injection in 0.9% Sodium Chloride Injection Containing Fructose Sodium[J].China Pharmaceuticals,2009,18(12):22-23. |
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| Authors: | Li Xuesong Qian Bin Yang Long Li Xiaojun Yan Yuanzhi Zou Shun |
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| Institution: | (Department of Pharmacy, First Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, China 650032) |
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| Abstract: | Objective To study the compatible stability of Fusidate Sodium for Injection in 0.9% Sodium Chloride Injection containing fructose sodium. Methods The content of the mixture in 0. 9% Sodium Chloride Injection were determined at different time by HPLC within 6 h; the appearance of the solution was observed and its pH was determined within 6 h. Results No significant differences were noted for the mixture in appearance, pH and contents within 6 h after mixing within 6 h. Conclusion The mixture of Fusidate Sodium for Injection in 0. 9% Sodium Chloride Injection containing fructose can be mixed to use within 6 h under the room temperature. |
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| Keywords: | fusidate fructose compatibility stability |
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