米非司酮治疗子宫肌瘤的五年疗效观察

目的 观察应用米非酮治疗子宫肌瘤的效果。方法 口服米非司酮１２．５ｍｇ，每日１次，连续３个月为一疗程。结果 ７８例中有６２例经过５年临床观察，子宫肌瘤体积缩小４１．８１％，用药过程中均闭经，贫血得以纠正。围绝经期可致绝经。因用药后肌瘤缩小，界限清楚，可作为子宫切除术和肌瘤剔除术术前用药，减少术中出血。结论 经５年观察，米非司酮治疗子宫肌瘤有临床应用价值。

Effect of mifepristone on the uterine leiomyoma by a five-year observation

Objective To study the effect of Mifepristone on the uterine leiomyoma.Methods Seventy eight patients with uterine leiomyoma was observed,each received 12.5mg mifepristone daily for 3 months.Results With 5 years observation,62 patients had a decreased volume of Leiomyoma,average 41.81% off.During treatment,improvement of hemoglobin and amenorrhea occurred.Menopause can even be seen in perimenopausal woman.Because leiomyoma became smaller and easier to be separated,mifepristone could be used before operation to reduce surgery bleeding.Conclusions Through 5 year observation,mifepristone has clinical value.