Multiple Pilomatricomas and Gliomatosis Cerebri—A New Association? |
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Authors: | Tina Wachter-Giner MD Imke Bieber MD † Monika Warmuth-Metz MD ‡ Eva-B Bröcker MD Henning Hamm MD |
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Institution: | Departments of Dermatology;, Pediatrics;, and Neuroradiology, University of Wuerzburg, Germany |
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Abstract: | Abstract: Pilomatricomas are benign skin tumors originating from hair follicle matrix cells. In 2% to 3.5% of cases they occur in multiplicity and then may be associated with genetic diseases, such as myotonic dystrophy Curschmann–Steinert, familial adenomatous polyposis (Gardner syndrome), and Rubinstein–Taybi syndrome. A 15-year-old boy treated with temozolomide and oxcarbazepine for gliomatosis cerebri with symptomatic epilepsy developed four firm cutaneous nodules on his face and right upper arm in the course of 1 year. All four tumors were excised under local anesthesia. Histological examination confirmed the clinical diagnosis of pilomatricomas. This is the first published case of a patient suffering from gliomatosis cerebri and developing multiple pilomatricomas. Whether this observation represents a new association or is a mere coincidence cannot be clarified at present. |
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