Effect of nociceptin on alcohol intake in alcohol-preferring rats |
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Authors: | Roberto Ciccocioppo Izabela Panocka Carlo Polidori Domenico Regoli M Massi |
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Institution: | (1) Department of Pharmacological Sciences and Experimental Medicine, University of Camerino, Via Scalzino 3, I-62032 Camerino, Italy e-mail: massi@cambio.unicam.it, Fax: +39-0737-630618, IT;(2) Department of Behavioural Physiology, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05–551 Mrokow, Poland, PL;(3) Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara, Via Fossato di Mortara, I-44100 Ferrara, Italy, IT |
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Abstract: | The present study investigated the effect of nociceptin (NC), the endogenous ligand of the opioid-like orphan receptor ORL1,
on ethanol intake in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats. Acute intracerebroventricular
(ICV) injection of 250 or 500 ng/rat of NC, just before access to 10% ethanol (offered 2 h/day), significantly increased ethanol
intake. Subchronic (7 days) ICV injection of 500 ng/rat of NC, given just before access to 10% ethanol (for 30 min/day), resulted
in a progressive decrease in ethanol consumption. After the end of NC treatment, rats progressively recovered their usual
ethanol intake. When NC, 500 or 1000 ng/rat, was tested versus the effect of ethanol in the place conditioning paradigm, NC
significantly reduced the increase in time spent in the ethanol-paired compartment after conditioning. This finding suggests
that NC reduces the rewarding properties of ethanol in msP rats; thus, they may respond to the acute NC administration by
increasing their ethanol intake in an attempt to achieve the usual reinforcing effect of ethanol, whereas subchronic NC treatment
may result in extinction of ethanol drinking. The results of the present study suggest that the brain NC mechanisms may represent
an interesting target of pharmacological interventions for the treatment of alcoholism.
Received: 11 August 1998/Final version: 15 October 1998 |
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Keywords: | Nociceptin Orphanin FQ Alcohol intake Marchigian Sardinian alcohol-preferring rat |
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