卢旺达产金盏菊花的黄酮苷类成分

目的对卢旺达产金盏菊花的化学成分进行研究,为进一步开发利用该植物资源提供依据。方法采用大孔吸附树脂、正相硅胶、Sephadex LH-20、反相ODS等柱色谱以及制备型高效液相色谱法等手段进行分离纯化,并通过理化性质与核磁共振等波谱学数据相结合的方法鉴定化合物的结构。结果从金盏菊花体积分数为70%的乙醇溶液提取物中分离鉴定了6个单体成分,分别为异鼠李素-3-O-芸香糖苷(isorhamnetin-3-O-rutinoside,1)、异鼠李素-3-O-新橙皮糖苷(isorhamnetin-3-O-neohespeidoside,2)、香蒲新苷(typhaneoside,3)、槲皮素-3-O-β-D-新橙皮糖苷(quercetin-3-O-β-D-neohespeidoside,4)、芦丁(rutin,5)、槲皮素-3-O-(2″,6″-二-O-α-L-鼠李糖基)-β-D-葡萄糖苷(quercetin-3-O-(2″,6″-di-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside,6)。结论首次对东非产金盏菊干燥花的化学成分进行研究,分离得到了6个黄酮类化合物。

The flavonoid glycosides from Rwandan Calendula officinalis L.

Objective To study the chemical constituents from Rwandan Calendula officinalis L. Methods The compounds w ere isolated by chromatographic methods such as D101,silica gel,ODS,Sephadex LH-20 and HPLC,and identified by the chemical and physical methods together w ith spectroscopic technologies including NMR and MS. Results Six flavonoid glycosides w ere isolated. The structures of them w ere identified as isorhamnetin-3-O-rutinoside( 1),isorhamnetin-3-O-neohespeidoside( 2),typhaneoside( 3),quercetin-3-O-β-D-neohespeidoside( 4),rutin( 5),and quercetin-3-O-( 2″,6″-di-O-α-L-rhamnopyranosyl)-β-D-glucoside( 6). Conclusions Compounds 1-4 and 6 are obtained from Calendula genus for the first time.