Subtyping and antifungal susceptibilities of Candida spp. in the intensive care unit of a Greek general hospital |
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Authors: | Kanellopoulou M Stamos G Petinnelli I Savala M Tzimogianni A Legakis N J Foustoukou M Papafragas E Velegraki A |
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Institution: | Department of Microbiology, Sismanoglion District General Hospital, Greece. |
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Abstract: | This study identified the Candida spp., susceptibility to antifungal agents and the prevailing Candida albicans subtypes responsible for infections or colonization of 42 patients in the ICU over a 6-month period. Most isolates were C. albicans (66.1%) and Candida tropicalis (28.3%) all of which were susceptible in vitro to antifungal agents. Subtypes of the C. albicans isolates were identified by pulsed field gel electrophoresis Sfi I chromosomal digests. Two major C. albicans subtypes were identified, whereas subtype heterogeneity was found among strains of Candida glabrata and C. tropicalis. Sfi I PFGE restriction patterns were able to discriminate between sub-populations of C. albicans isolates, clustering them into distinct, epidemiologically congruous groups. |
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