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Macrophage-mediated cytostatic activity on tumour cells after treatment with Triton WR 1339 |
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| Authors: | A Mantovani N Polentarutti M Sironi A Vecchi F Spreafico S Garattini |
| Affiliation: | 1. Laboratory of Cancer Epigenetics, Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow 226 031, India;2. Department of Biology, University of Alabama at Birmingham, AL 35294, USA;3. Academy of Scientific and Innovative Research (AcSIR), New Delhi, India |
| Abstract: | Peritoneal macrophages collected from mice treated with schedules of Triton WR 1339 previously shown to inhibit metastasis formation in experimental tumour models were found to nonspecifically inhibit growth and DNA synthesis of tumour cells in vitro. No significant lysis of51Cr-labelled target cells could de detected. It is suggested that activation of macrophage-mediated cytostasis may contribute to the antimetastatic activity of Triton WR 1339. |
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