Laminin-dependent inflammatory response in synovial fibroblasts of rheumatoid arthritis patients |
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| Authors: | Aicher W K Pap T Gay S |
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| Affiliation: | Zentrum für Medizinische Forschung, Orthop?dische Universit?tsklinik, Eberhard-Karls-Universit?t Tübingen, Hoppe-Seyler-Strasse 3, 72076, Tübingen, Deutschland. Aicher@uni-tuebingen.de |
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| Abstract: | Elevated expression of matrix-metalloproteinases (MMP) contributes to cartilage destruction in rheumatoid arthritis. We report on a novel pathway of inflammatory activation of synovial fibroblasts that is induced by TGF-beta and laminin (extracellular matrix) and leads to increased expression of the proteases MMP-3 and MMP-10. Neither costimulation by the central inflammatory cytokines TNF-alpha and IL-1beta nor NFkB signalling is needed for this pathway. |
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