| 核仁组织区在口腔粘膜癌变过程中表达的变化 |
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| 引用本文： | 聂敏海,胡佳,冯燕. 核仁组织区在口腔粘膜癌变过程中表达的变化[J]. 泸州医学院学报, 2006, 29(2): 98-99 |
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| 作者姓名： | 聂敏海 胡佳 冯燕 |
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| 作者单位： | 泸州医学院附属口腔医院口腔内科,四川,泸州,646000 |
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| 摘 要： | 目的:比较口腔粘膜癌变过程中核仁组织区(NOR)的变化及与癌变趋势的关系.方法:选取人正常及不同病变的口腔粘膜,采用胶体银染色法检测NOR,分析AgNOR的位置形态和AgNOR颗粒面积与核面积的比值.结果:正常口腔粘膜AgNOR颗粒主要见于上皮基底层,形态学分型为单一型;重度上皮异常增生以聚集型为主,部分为弥散型;口腔鳞状细胞癌主要为聚集型,部分为核仁内型.随着病变程度和异常增生程度加重,AgNOR颗粒面积与细胞核面积比值增加.结论:AgNOR表达在口腔粘膜癌变过程中逐渐增强.
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| 关 键 词： | 银染核仁组织区 癌前病变 口腔粘膜 |
| 文章编号： | 1000-2669(2006)2-0098-02 |
| 收稿时间： | 2005-10-11 |
| 修稿时间： | 2005-10-11 |
CHANGES OF EXPRESSION OF NUCLEOLAR ORGANIZER REGIONS DURING ORAL CARCINOGENESIS |
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| Nie Minhai ,et al. CHANGES OF EXPRESSION OF NUCLEOLAR ORGANIZER REGIONS DURING ORAL CARCINOGENESIS[J]. Journal of Luzhou Medical College, 2006, 29(2): 98-99 |
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| Authors: | Nie Minhai et al |
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| Affiliation: | Dental Hospital, Luzhou Medical College |
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| Abstract: | Objective: To study the relation between nucleolar oryanizer regions(NOR) and the trend of carcinomatous changes during oral carcinogenesis.Methods: 6 normal human oral mucosa,6 simple hyperplasia,22 dysplasia,and and 7 oral squamous cell carcinoma cases were tested with the method of silver staining for the expression of NOR.Results: AgNOR was found to locate in the basal cell layer of normal mucosa,mainly in a single form.Most of the severe dysplasia express AgNOR in an aggregated form and some express AgNOR in a diffuse form.In most of the squamous cell carcinoma expressed AgNOR in aggregated form and some in inter-nucleolus form.Conclusion:The expression of AgNOR increases gradually during oral carcinogenesis. |
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| Keywords: | AgNOR Precancerous lesioni Oral mucosa |
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